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Clinical Chemistry 16: 637-642, 1970;
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Clinical Chemistry, Vol 16, 637-642, Copyright © 1970 by the American Association for Clinical Chemistry

Method for Resolving and Measuring Overlapping Chromatographic Peaks by Use of an On-Line Computer with Limited Storage Capacity

Charles D. Scott 1, Dennis D. Chilcote 1, and W. Wilson Pitt Jr. 1

1 Oak Ridge National Laboratory, Oak Ridge, Tenn. 37830. (Operated for the U. S. Atomic Energy Commission by Union Carbide Corp.)

A simple routine for distinguishing and measuring the positions and areas of overlapping peaks comprising a complex chromatographic "envelope" has been developed for a small on-line computer. The degree of peak overlap is such that no minima and only one maximum occur within the bounds of the envelope. This routine determines corrected initial estimates of the Gaussian parameters of the peaks. The routine is currently being used, in conjunction with a program devised to analyze data generated by a chromatographic system, specifically to evaluate data from high-resolution analyzers.


Key Words: peak stripping • physiological fluid analysis • column chromatography • mathematical peak envelope analysis • Taylor series expansion






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