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Clinical Chemistry 16: 657-661, 1970;
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Clinical Chemistry, Vol 16, 657-661, Copyright © 1970 by the American Association for Clinical Chemistry

A Bench-Top, Automated, High-Resolution Analyzer for Ultraviolet Absorbing Constituents of Body Fluids

W. Wilson Pitt Jr. 1, Charles D. Scott 1, Wayne F. Johnson 1, and Guy Jones Jr. 1

1 Oak Ridge National Laboratory, Oak Ridge, Tenn. 37830. (Operated for the U.S. Atomic Energy Commission by Union Carbide Corp.)

An automated, high-resolution chromatograph capable of separating as many as 150 ultraviolet-absorbing molecular constituents of body fluids has been previously developed. A smaller, improved version of this analyzer, which uses only one-eighth of the previously required quantity of ion-exchange resin, sample, and eluant, is described. Analysis time has been decreased from 40 to 20 h. A prototype system of this analyzer, which will fit on an ordinary laboratory bench top, has been built and is now being tested. The small prototype analyzer uses a folded, 0.22-cm ion-exchange column for separation and a recently developed dual-beam, dual-wavelength, uv-flow photometer for detection. A unique device has been developed to generate the buffer concentration gradient used in eluting the ion-exchange column. Analyses of body fluids with this prototype are comparable to those achieved with the larger analyzers.


Key Words: anion-exchange chromatography • buffer gradient device




The following articles in journals at HighWire Press have cited this article:


Home page
 ScienceHome page
C. D. Scott
High-Pressure Ion Exchange Chromatography
Science, October 18, 1974; 186(4160): 226 - 233.
[PDF]

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 ScienceHome page
C. D. Scott
Health Care Delivery and Advanced Technology
Science, June 29, 1973; 180(4093): 1339 - 1342.
[Abstract] [PDF]


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Copyright © 1970 by the American Association for Clinical Chemistry.