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Clinical Chemistry 16: 697-701, 1970;
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Clinical Chemistry, Vol 16, 697-701, Copyright © 1970 by the American Association for Clinical Chemistry

Serum Organic Acids in Sheep Exposed to Neutron—Gamma Irradiation, Air Blast, or Both

Thomas R. Henderson 1 and Robert K. Jones 1

1 Department of Biochemistry, Lovelace Foundation for Medical Education and Research, Albuquerque, N. M. 87108.

Organic acids were measured in serum from sheep that had been exposed to neutron—gamma irradiation, air blast, or both to determine which concentrations change after experimental injury. Samples were directly analyzed by partition chromatography and indicator titration. The semiautomated instrument efficiently separates mixtures of monocarboxylic acids. Monocarboxylic acids in serum seem to be sensitive indicators of biological injury. Survey experiments showed that lactate and propionate accumulate in sheep serum after severe air-blast injury, but only propionate after irradiation. Propionate-loading studies suggested that the utilization of injected propionate is impaired, to various degrees, in fasting, irradiation, and air blast. However, presumptive impairment of propionate utilization occurred earlier in sheep exposed to irradiation and blast than in only irradiated animals, and earlier in irradiated animals than in fasting controls. Air blast exposure resulted in effects of only borderline significance.


Key Words: silicic acid column chromatography • propionate utilization • propionate tolerance test • survival times • monocarboxylic acids






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