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Clinical Chemistry 16: 702-706, 1970;
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Clinical Chemistry, Vol 16, 702-706, Copyright © 1970 by the American Association for Clinical Chemistry

Ultraviolet-Absorbing Compounds in Urine of Normal Newborns and Young Children

Joel M. Vavich 1 and R. Rodney Howell 1

1 Department of Pediatrics, Johns Hopkins University School of Medicine, and the Harriet Lane Service, Johns Hopkins Children’s Medical and Surgical Center, Baltimore, Md. 21205.

Ultraviolet-absorbing compounds excreted in the urine of normal newborns, infants, and children have been measured by high-pressure anion-exchange chromatography. The chromatograms increased in complexity with increasing age of the subject. Preliminary data indicate that the excretion of pseudouridine and uridine was significantly higher in newborns and infants than in older children and adults. Excretion of hippuric acid was low in the newborn. Excretion of ergothioneine was lower in older children than in newborns, infants, or adults. However, hypoxanthine excretion was constant in all groups.


Key Words: pseudouridine • uridine • hippuric acid • hypoxanthine • ergothioneine • column chromatography • effects of diet • creatinine, reliability of, as excretion index






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