Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 16: 707-713, 1970;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kelley, W. N.
Right arrow Articles by Wyngaarden, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kelley, W. N.
Right arrow Articles by Wyngaarden, J. B.

Clinical Chemistry, Vol 16, 707-713, Copyright © 1970 by the American Association for Clinical Chemistry

Effect of Dietary Purine Restriction, Allupurinol, and Oxipurinol on Urinary Excretion of Ultraviolet-Absorbing Compounds

William N. Kelley 1 and James B. Wyngaarden 1

1 Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, N.C. 27706.

We demonstrate that purine restriction is associated with a decreased excretion of a number of uv-absorbing compounds—including uric acid, hypoxanthine, xanthine, adenine, pseudouridine, and 5-acetylamino-6-amino-3-methyluracil—indicating that these compounds originate, at least partly, exogenously. Administration of allopurinol and oxipurinol is associated with a decreased excretion of uric acid and an increased excretion of hypoxanthine and xanthine, as well as the excretion of the previously identified products of allopurinol and oxipurinol metabolism. Moreover, these drugs further decrease excretion of 5-acetylamino-6-amino-3-methyluracil, increase uracil excretion slightly, and strikingly increase orotic acid and orotidine excretion. No change in pseudouridine excretion was observed. The ultraviolet-analyzer is a valuable tool for detecting qualitative changes in the excretion of ultraviolet-absorbing compounds in the urine; with it, identified peaks can be semiquantitated.


Key Words: 5-acetyl-6-amino-3-methyluracil • orotic acid • orotidine • pseudouridine • uric acid and its metabolic precursors • adenine • allopurinol ribonucleoside • anion-exchange chromatography • normal values




The following articles in journals at HighWire Press have cited this article:


Home page
 ScienceHome page
C. D. Scott
High-Pressure Ion Exchange Chromatography
Science, October 18, 1974; 186(4160): 226 - 233.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1970 by the American Association for Clinical Chemistry.