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Clinical Chemistry 16: 714-721, 1970;
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Clinical Chemistry, Vol 16, 714-721, Copyright © 1970 by the American Association for Clinical Chemistry

Ultraviolet-Absorbing Components of Urine from Mentally Retarded Children. III

Elaine W. Lis 1, Adam W. Lis 1, and Konrad F. deHackbeil 1

1 Nucleic Acids Laboratory, Department of Obstetrics and Gynecology, and the Multiple Discipline Clinic, Crippled Children’s Division, University of Oregon Medical School, Portland, Ore. 97201.

Urinary excretion of ultraviolet light-absorbing end-products of metabolism was studied in mentally retarded children and a single plasma dialysate from a nephrectomized adult male. Aliquots were fractionated on Dowex-1 columns with 1 mol/liter and 4 mol/liter formic acid gradients. Resolved peaks were pooled and suitable aliquots submitted to two-dimensional ascending paper chromatography. Among previously unidentified components, 5-alkyl substituted uracil was found in the plasma dialysate obtained from the nephrectomized male. Citrullinemia was shown to be associated with a high excretion of what we believe to be orotic acid. Another familial disorder of central nervous system function complicated by mental retardation and aggressive destructive behavior (not Lesch-Nyhan syndrome) was characterized on the basis of a urinary metabolic profile. In some mentally retarded children, excretion of creatinine varied enormously. Creatinine, submitted to a systematic, quantitative procedure for assessing the behavioral and physiologic state in mice, had properties of a weak minor tranquilizer; its sedative attributes may be responsible for light sleep preconditioning.


Key Words: creatinine excretion • catabolites • plasma dialysate, compounds in • citrullinemia and orotic acid excretion • sleep induction • ion-exchange chromatography • ammoniemia • N-methyl-2-pyridone-5-carboxamide • 5-ribosyluracil • t-RNA • pseudouridine • normal values • autism • artificial kidney dialysate






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Copyright © 1970 by the American Association for Clinical Chemistry.