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Clinical Chemistry 16: 763-765, 1970;
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Clinical Chemistry, Vol 16, 763-765, Copyright © 1970 by the American Association for Clinical Chemistry

Semiautomated Method for Measurement of Dopa in Plasma

Herbert E. Spiegel 1 and Alice E. Tonchen 1

1 Clinical Biochemistry Laboratory, Department of Clinical Pharmacology, Hoffmann-La Roche Inc., Nutley, N.J. 07110.

A semiautomated fluorometric method for analysis of dopa [3-(3,4-dihydroxyphenyl)-L-alanine] is described, with ferricyanide used as an oxidant. To separate dopa from interfering catecholamines it is adsorbed on alumina, eluted with 0.1N HCl, then adsorbed on and eluted from a cation-exchange column. The method is suitable for use with a large volume of samples. It provides a simple, sensitive, accurate, and reproducible analytical technique for routine use.


Key Words: fluorometry • dihydroxyphenylalanine • cation-exchange chromatography • AutoAnalyzer • ferricyanide oxidant

Submitted on April 25, 1970
Accepted on June 2, 1970




The following articles in journals at HighWire Press have cited this article:


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 ScienceHome page
R. Hoeldtke, B. S. Baliga, P. Issenberg, and R. J. Wurtman
Dihydroxyphenylalanine in Rat Food Containing Wheat and Oats
Science, February 18, 1972; 175(4023): 761 - 762.
[Abstract] [PDF]


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Copyright © 1970 by the American Association for Clinical Chemistry.