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Clinical Chemistry 16: 781-785, 1970;
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Clinical Chemistry, Vol 16, 781-785, Copyright © 1970 by the American Association for Clinical Chemistry

A Discussion of the Linearity between the Measured Voltages of Ion-Selective Electrodes and the Ionic Concentrations in Whole Blood

G. W. Neff 1

1 International Business Machines Corp., Advanced Systems Development Division, 2651 Strang Blvd., Yorktown Heights, N.Y. 10598.

The ion-sensitive electrodes used to measure Na+, K+, and Cl- in biological fluids have output voltages that are logarithmically related to ionic activity. This measured voltage also is linearly related to ionic concentration for the Na+ and Cl- electrodes. Furthermore, the K+ electrode, which must be corrected for its Na+ sensitivity in whole blood or plasma, exhibits a linear characteristic between measured voltage and K+ concentration in which the constants of the straight-line equation are each a linear function of the Na+ concentration. The linear relationships are discussed and fitted to data for pure electrolyte solutions, plasma, and whole blood.


Key Words: sodium, potassium, chloride in biological fluids • plasma • automatic blood analyzer

Submitted on February 9, 1970
Accepted on June 2, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.