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Clinical Chemistry 16: 786-788, 1970;
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Clinical Chemistry, Vol 16, 786-788, Copyright © 1970 by the American Association for Clinical Chemistry

Amphetamines in Human Urine: Rapid Estimation by Gas—Liquid Chromatography

J. W. Schweitzer 1 and A. J. Friedhoff 1

1 New York University School of Medicine, 550 First Ave., New York, N.Y. 10016.

A procedure is described for the quantitative determination of amphetamine and p-methoxyamphetamine and for the semiquantitative determination of methamphetamine, mephentermine, and normephentermine in human urine. An internal reference compound, phenethylamine, is added to 5 ml of urine. The urine is extracted at low pH to remove acidic contaminants, then at high pH with chloroform, in which the amines were acetylated with acetic anhydride. After evaporation, the residue, dissolved in dioxane, is injected onto a column at 215°C, packed with 8% ethyleneglycol adipate on Chromosorb W, 100-120 mesh, except at both ends, where the packing was 8% silicon rubber SE 30 on Chromosorb W, 100-120 mesh. The excretion rate of amphetamines by patients admitted with a diagnosis of amphetamine psychosis was measured.


Key Words: p-methoxyamphetamine • hallucinogen • N,agr-dimethylamphetamine (mephentermine) • agr-methylamphetamine (normephentermine) • N-methylamphetamine (methamphetamine, d-desoxyephedrine hydrochloride) • excretion rates after oral doses • phenethylamine, internal standard

Submitted on March 7, 1970
Accepted on June 22, 1970






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Copyright © 1970 by the American Association for Clinical Chemistry.