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Clinical Chemistry 17: 27-30, 1971;
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Clinical Chemistry, Vol 17, 27-30, Copyright © 1971 by the American Association for Clinical Chemistry

Direct Potentiometric Determination of Potassium and Sodium in Blood, Plasma, and Serum

Don S. Miyada 1, Kazuko Inami 1, and George Matsuyama 1

1 Orange County Medical Center, 101 S. Manchester Ave., Orange, Calif. 92668 (D.S.M., K.I.); and Beckman Instruments, Inc., 2500 Harbor Blvd., Fullerton, Calif. 92634 (G.M., to whom reprints should be addressed).

A potentiometric analyzer, developed to directly measure potassium and sodium concentrations, was evaluated on aqueous solutions, whole blood, serum, and plasma. The analyzer consists of three electrodes—sodium, potassium, and reference—mounted in a flow-cell configuration, and a modified digital pH meter, which displays the ion concentrations directly. Volume of the cell is about 100 µl. The electrodes equilibrate to each new sample in less than a minute. Calibrated with aqueous standard solution, the system yields essentially the same values for whole blood and the corresponding plasma, and results agree with those obtained for the same samples of plasma by flame photometry.


Key Words: Beckman Potentiometric Analyzer • ion-selective electrodes • flame photometry vs. potentiometry • Nernst and Nicolsky equations

Accepted on October 17, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.