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Clinical Chemistry 17: 31-33, 1971;
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Clinical Chemistry, Vol 17, 31-33, Copyright © 1971 by the American Association for Clinical Chemistry

The In Vitro Sensitivity of Erythrocyte Aggregation to Quinine: Assessment by a Serial Blood Sedimentation Procedure

R. C. Robbins 1 and James E. Harbin Jr. 1

1 Department of Food Science, University of Florida, Gainesville, Fla. 32601.

A serial erythrocyte sedimentation procedure is based on maintaining blood in vitro in thermal (body temperature) and flow equilibrium, as changes in sedimentation rate are evaluated at 20-min intervals. Each measurement was made 1 h after the determination was begun. We thus confirmed in vitro the clinically observed effects of quinine on blood cell aggregation. A delayed effect of quinine on aggregation corresponded to in vivo observations that aggregation is first affected 3 to 12 h after the drug is administered. Quinine’s greatest effect (p < 0.01) on erythrocyte sedimentation in vitro was at 200 min with 2 mg of quinine per 100 ml of blood, 220 min with 1 mg/100 ml, and 240 min with 0.5 mg/l00 ml.


Key Words: horse • in vivo results compared

Accepted on October 19, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.