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Clinical Chemistry 17: 42-48, 1971;
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Clinical Chemistry, Vol 17, 42-48, Copyright © 1971 by the American Association for Clinical Chemistry

Origin of the Lag Phase of Continuous-Flow Analysis Curves

Ralph E. Thiers 1, Allen H. Reed 1, and Karen Delander 1

1 Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405.

Physical and mathematical models are presented that account for the lag phase in the curves of transition between steady states in continuous-flow analysis. Experimental conditions are described that produce pure lag-phase curves, separated from the exponential phase with which they are combined in routine practice. The data quantitatively support the expectations from the models, and provide a means for measuring interslug transfer of fluid in bubbled streams. Others observed earlier that lag phase is associated with the bubbled stream and the dialyzer, whereas the exponential phase is associated with nonbubbled streams and debubbler [Clin. Chim. Acta 27, 421 (1960)]. Our theory and experiments confirm these earlier observations, and may provide deeper understanding of the processes involved in, and design requirements for, continuous-flow analysis.


Key Words: mathematical models and observed phenomena • fluid transfer between slugs in bubbled streams • dialyzer fluid mechanics • AutoAnalyzers

Accepted on October 19, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.