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Clinical Chemistry 17: 49-50, 1971;
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Clinical Chemistry, Vol 17, 49-50, Copyright © 1971 by the American Association for Clinical Chemistry

A Quick Method for Definitively Diagnosing Phenylketonuria by Detection of Urinary o-Hydroxyphenylacetic Acid

Theodore N. Hackett Jr. 1 and Patrick F. Bray 1

1 Division of Pediatric Neurology, University of Utah College of Medicine, Salt Lake City, Utah 84112.

Increased urinary excretion of o-hydroxyphenylacetic acid is a generally accepted sign of phenylketonuria. Most reported methods for measuring this metabolite require 24 h. We describe a procedure for its separation in 90 min by thin-layer chromatography. Thus, essential dietary therapy is speeded.

Accepted on November 7, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.