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Clinical Chemistry 17: 1024-1027, 1971;
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Clinical Chemistry, Vol 17, 1024-1027, Copyright © 1971 by the American Association for Clinical Chemistry

A Gas-Chromatographic Method for Separating and Measuring Barbiturates and Glutethimide in Blood

Ermalinda A. Fiereck 1 and Norbert W. Tietz 1

1 Mount Sinai Hospital Medical Center and The Chicago Medical School University of Health Sciences, California Ave. at 15th St., Chicago, Ill. 60608.

A gas-chromatographic method is described for the quantitative determination of 11 barbiturates and glutethimide in blood. The extracted barbiturates are methylated and injected into a 7% DC-200 column. Use of methohexital as the internal standard, as well as the addition of standards to a drug-free sample of blood, compensates for losses and for differences in the distribution coefficient of the individual barbiturates, and makes the procedure highly precise and accurate.


Key Words: drug abuse

Submitted on May 24, 1971
Accepted on July 21, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.