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Clinical Chemistry 17: 1129-1131, 1971;
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Clinical Chemistry, Vol 17, 1129-1131, Copyright © 1971 by the American Association for Clinical Chemistry

Amino Acid Transport and Mental Retardation

H.-D. Gruemer 1, G. F. Grannis 1, L. B. Hetland 1, and M. L. Costantini 1

1 Division of Clinical Chemistry, Department of Pathology, The Ohio State University, Columbus, Ohio 43210.

Overlapping transport specificity may permit amino acid concentrations in brain to readjust to a new (lower) equilibrium in a compensatory response to increased concentrations of a "model" amino acid in serum. If this is true for analogous clinical situations, it may help explain the effects of phenylketonuria on mentation.


Key Words: inborn errors of metabolism • amino acid transport in brain • mechanism of mental retardation

Submitted on June 4, 1971
Accepted on June 18, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.