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Clinical Chemistry 17: 1132-1133, 1971;
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Clinical Chemistry, Vol 17, 1132-1133, Copyright © 1971 by the American Association for Clinical Chemistry

Rapid Column-Chromatographic Measurement of Orotic Acid

John F. Bellinger 1 and Neil R. M. Buist 1

1 Departments of Pediatrics and Medical Genetics, University of Oregon Medical School, 3181 S.W. Sam Jackson Park Road, Portland, Ore. 97201.

A rapid anion-exchange column-chromatographic method for measuring orotic acid is described. The method is of value in screening or quantitating abnormal amounts of this compound, but cannot be used to measure the small amounts normally present in urine.


Key Words: orotic aciduria • citrullinemia • 6-azauridine • ornithine transcarbamylase deficiency • uv-detection

Submitted on May 17, 1971
Accepted on June 21, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.