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Clinical Chemistry 17: 1176-1179, 1971;
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Clinical Chemistry, Vol 17, 1176-1179, Copyright © 1971 by the American Association for Clinical Chemistry

Studies on Leukocyte Phosphatases. III. Inhibition of Leukocyte Acid Phosphatase by Zinc

Lawrence R. DeChatelet 1, M. Robert Cooper 1, and Charles E. McCall 1

1 Departments of Biochemistry and Medicine, The Bowman Gray School of Medicine, Winston-Salem, N. C. 27103.

Whereas the activity of leukocyte alkaline phosphatase is stimulated by Zn2+, it inhibits acid phosphatase activity. The degree of inhibition of acid phosphatase depends on the pH of the medium, being greater as the pH approaches neutrality. This inhibition may be at least partially reversed by the addition of amino acids, which suggests that interactions of Zn2+ and amino acids may play an important role in regulating the overall phosphatase activity of the leukocyte.


Key Words: phosphatase activity, in vivo control • amino acid— Zn2+ chelation

Submitted on August 10, 1971




The following articles in journals at HighWire Press have cited this article:


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[Abstract] [Full Text] [PDF]


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Copyright © 1971 by the American Association for Clinical Chemistry.