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Clinical Chemistry 17: 115-118, 1971;
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Clinical Chemistry, Vol 17, 115-118, Copyright © 1971 by the American Association for Clinical Chemistry

L-Benzylalanine as a Model Amino Acid for the Study of Accumulation Diseases

H.-D. Grümer 1, L. B. Hetland 1, and M. L. Costantini 1

1 Department of Pathology and the Division of Clinical Chemistry, The Ohio State University, 410 W. 10th Ave., Columbus, Ohio 43210.

L-Benzylalanine, like phenylalanine, accumulates in vivo when fed to rats, leading to diminished uptake of a number of amino acids into brain without a corresponding change in serum. The similar effects of benzylalanine and phenylalanine on other brain amino acids in the experimental animal, as well as some similarity of the catabolism of these two amino acids, adds benzylalanine to the list of compounds that can simulate an accumulation disease.


Key Words: phenylketonuria • uptake of amino acids by brain • experimental neurochemistry • rats

Submitted on October 14, 1970
Accepted on November 9, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.