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Clinical Chemistry 17: 148-151, 1971;
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Clinical Chemistry, Vol 17, 148-151, Copyright © 1971 by the American Association for Clinical Chemistry

Effects of Treatment on Tyrosine Tolerance in Thyroid Disease

A Modified Tyrosine Assay

Trevor Williams 1 and Gordon M. Besser 1

1 Medical Professorial Unit, St. Bartholomew’s Hospital, London, E.C.1, England.

A widely used assay technique for plasma tyrosine determination has been found to give rise to large errors. It was modified to improve accuracy, and the relationship between the values derived by the modified and unmodified procedures was studied. The plasma tyrosine concentrations in thyrotoxic and hypothyroid patients during oral tyrosine loading are reported. Tyrosine tolerance in thyrotoxicosis reverts to normal after successful treatment. In hypothyroidism, most patients had normal tyrosine tolerance before and after treatment.


Key Words: fluorometry • thyrotoxicosis • hypothyroidism • TSH

Submitted on August 25, 1970
Accepted on December 15, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.