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Clinical Chemistry 17: 156-157, 1971;
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Clinical Chemistry, Vol 17, 156-157, Copyright © 1971 by the American Association for Clinical Chemistry

Normal Clinical Chemical Values for Pregnant Women at Term

Joseph R. Elliott 1 and Richard T. O’Kell 1

1 St. Luke’s Hospital, Kansas City, Mo. 64111.

Results for clinical chemical determinations on serum of 20 to 39-year-old pregnant women at term were compared (SMA 12/60) with those for nonpregnant women in the same age group. Sera from the pregnant group had higher mean uric acid and cholesterol concentrations; higher mean alkaline phosphatase, lactic dehydrogenase, and glutamic oxaloacetic transaminase activities; and lower mean glucose, urea nitrogen, protein, and albumin concentrations. All differences are significant (P <0.001). Phosphorus and bilirubin concentrations did not differ significantly for the two groups. The increase in alkaline phosphatase activity in the pregnant group is evidently due to a heat-stable fraction, which does not correlate (at term) with number of weeks gestation, infant sex, infant weight, or placental weight. Forty women who had high concentrations of serum uric acid showed no signs of toxemia of pregnancy and delivered normal infants.


Key Words: AutoAnalyzer • SMA 12/60 • uric acid and toxemia • alkaline phosphatase

Submitted on April 3, 1970
Accepted on December 24, 1970




The following articles in journals at HighWire Press have cited this article:


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 NEJMHome page
T. A. Knox and L. B. Olans
Liver Disease in Pregnancy
N. Engl. J. Med., August 22, 1996; 335(8): 569 - 576.
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