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Clinical Chemistry 17: 166-173, 1971;
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Clinical Chemistry, Vol 17, 166-173, Copyright © 1971 by the American Association for Clinical Chemistry

Measurement of "Free" Thyroxine in Serum

Norman D. Lee 1 and Vincent J. Pileggi 1

1 Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405.

A dialysis method for determining "free" thyroxine in diluted serum is presented. The effect of a number of variables (pH, incubation time and temperature, buffer composition and concentration, protein concentration, and specimen dilution) was studied, and pertinent data are presented. Within-run precision (95% confidence limits) was ±10.6%; between-run precision was ±14.2%. Specimens from 84 healthy subjects were analyzed, and normal ranges are presented. The method has been used for five years, and has been found to be simple and suited to simultaneous analysis of large numbers of specimens.


Key Words: dialysis of "free" thyroxine • normal ranges • thyroxine-131I • concept of "free" thyroxine • absorption to vessels

Submitted on October 7, 1970
Accepted on December 29, 1970






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Copyright © 1971 by the American Association for Clinical Chemistry.