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Clinical Chemistry 17: 210-213, 1971;
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Clinical Chemistry, Vol 17, 210-213, Copyright © 1971 by the American Association for Clinical Chemistry

Studies on Leukocyte Phosphatases

II. Inhibition of Leukocyte Alkaline Phosphatase by Amino Acids and Its Reversal by Zinc

Lawrence R. DeChatelet 1, James V. Volk 1, Charles E. McCall 1, and M. Robert Cooper 1

1 Departments of Biochemistry and Medicine, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, N.C. 27103.

The activity of leukocyte alkaline phosphatase is inhibited by a number of amino acids, most notably cysteine and histidine. The mechanism of this inhibition involves chelation of Zn2+ by the amino acids, as indicated by the complete reversal of the inhibition by added Zn2+. The concentrations of amino acids and Zn2+ required to affect the enzyme activity are such that their interaction might represent an in vivo mechanism for the control of leukocyte alkaline phosphatase activity.


Key Words: physiological control of phosphatase activity • Zn2+ as cofactor • chelation by amino acids

Submitted on December 8, 1970
Accepted on January 5, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.