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Clinical Chemistry 17: 275-284, 1971;
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Clinical Chemistry, Vol 17, 275-284, Copyright © 1971 by the American Association for Clinical Chemistry

Influence of Statistical Method Used on the Resulting Estimate of Normal Range

Allen H. Reed 1, Richard J. Henry 1, and William B. Mason 1

1 Bio-Science Laboratories, 7600 Tyrone Ave., Van Nuys, Calif. 91405.

The choice of statistical method can greatly influence the calculated normal range apart from any biological or chemical considerations. Nonparametric normal range estimates are, for practical purposes, as accurate as estimates that assume the distribution of data to be gaussian or loggaussian when the distribution assumed is true. When data are not distributed as assumed, nonparametric estimates are more accurate.


Key Words: haptoglobin data • k factor method • chi-square test • Kolmogorov—Smirnov test • nonparametric estimates • gaussian and log-gaussian distribution of data • outliers • no. samples for estimate

Accepted on February 1, 1971




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Copyright © 1971 by the American Association for Clinical Chemistry.