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Clinical Chemistry 17: 335-338, 1971;
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Clinical Chemistry, Vol 17, 335-338, Copyright © 1971 by the American Association for Clinical Chemistry

Isolation of Glycoproteins from Human Gastric Juice and Saliva by Density Gradient Ultracentrifugation

M. A. Denborough 1, J. C. Presser 1, and Berta Ungar 1

1 University of Melbourne Department of Medicine and Department of Clinical Pathology, The Royal Melbourne Hospital, Victoria, Australia 3050.

Density gradient equilibrium ultracentrifugation has been used successfully to isolate the glycoproteins from human gastric juice and saliva. Analysis of the fractions obtained by this method has shown that blood-group substance glycoproteins are the major component of glycoprotein secretion in both gastric juice and saliva. The technique also separates intrinsic factor and the nonspecific B12-binding substance from the blood-group substance glycoproteins in gastric juice. The nonspecific B12-binding substances in both gastric juice and saliva have a similar density and appear to consist of a single family of molecules.


Key Words: blood-group specific glycoproteins • intrinsic factor • nonspecific B12-binding substances

Submitted on January 27, 1971
Accepted on February 4, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.