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Clinical Chemistry 17: 388-391, 1971;
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Clinical Chemistry, Vol 17, 388-391, Copyright © 1971 by the American Association for Clinical Chemistry

Enhanced Excretion of Free Amino Acids by Hyperthyroid Patients

John H. Felts 1 and J. Stanton King Jr. 1

1 Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, N. C. 27103.

Greater than normal amounts of one or more amino acids were found in the urines of 20 of 24 thyrotoxic patients. The amino acids most commonly increased were tyrosine (in nine of the 24 patients), beta-aminoisobutyric acid (11/24), and cystathionine (12/24); seven patients had concurrent increases in the latter two amino acids. Hyperaminoacidemia, accompanied by generalized hyperaminoaciduria, was seen in the three nonfasting patients whose urine was examined. Sera from patients fasted overnight contained normal concentrations of free amino acids. Urinary calcium exceeded 250 mg/24 h in 10 of the 24 patients; urinary phosphorus exceeded 1.2g/day in four. These variables correlated poorly with each other, with the diagnostic impression of severity, and with the results of thyroid-function tests.


Key Words: urinary calcium and phosphorus • serum amino acids • thyroid-function tests, correlation • malignant exophthalmos • effects of treatment

Submitted on January 25, 1971
Accepted on February 22, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.