Clinical Chemistry
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Clinical Chemistry 17: 423-426, 1971;
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Clinical Chemistry, Vol 17, 423-426, Copyright © 1971 by the American Association for Clinical Chemistry

Macroamylasemia: Rapid Detection Method

Louis Fridhandler 1, J. Edward Berk 1, and Masatoshi Ueda 1

1 Department of Medicine, University of California, Irvine, Calif. 92664.

A reliable method is presented for rapidly screening human sera to detect macroamylasemia. A mixture of the serum to be tested, Blue Dextran, and cytochrome c is filtered through a small column of cross-linked dextran gel (Sephadex G-100). Amylase in the effluent fractions is detected by incubation with amylose and subsequent addition of iodine. Macroamylase, if present, is found in the blue-colored fractions, while amylase of normal molecular weight appears in the fractions colored by cytochrome c.


Key Words: gel filtration • cytochrome c and Dextran Blue as markers • diagnostic screening • hyperamylasemia

Submitted on February 15, 1971
Accepted on March 16, 1971




The following articles in journals at HighWire Press have cited this article:


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 ANN INTERN MEDHome page
M. B. BLOCK, J. E. BERK, L. S. FRIDHANDLER, D. F. STEINER, and A. H. RUBENSTEIN
Diabetic Ketoacidosis Associated with Mumps Virus Infection: Occurrence in a Patient with Macroamylasemia
Ann Intern Med, May 1, 1973; 78(5): 663 - 667.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
R. W. AMMANN, J. E. BERK, L. FRIDHANDLER, M. UEDA, and W. WEGMANN
Hyperamylasemia with Carcinoma of the Lung
Ann Intern Med, April 1, 1973; 78(4): 521 - 525.
[Abstract] [PDF]


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