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Clinical Chemistry 17: 430-432, 1971;
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Clinical Chemistry, Vol 17, 430-432, Copyright © 1971 by the American Association for Clinical Chemistry

Separation of Proteins in Concentrated Cerebrospinal Fluid by Two-Dimensional Electrophoresis in Acrylamide Gel

G. L. Wright Jr. 1

1 Department of Microbiology, George Washington University, School of Medicine, Washington, D. C. 20005.

Two-dimensional electrophoresis in acrylamide was used to separate the proteins in concentrated cerebrospinal fluid (CSF). More than 60 such components could be detected, twice as many as separated by conventional polyacrylamide techniques. Many of the proteins were common to CSF and serum. The high resolution attainable with this procedure may make it useful in detecting specific CSF alterations associated with neurologic diseases.


Key Words: genetic polymorphism • lipoproteins • "electroprotein mapping" • isoenzymes

Submitted on January 18, 1971
Accepted on March 15, 1971







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Copyright © 1971 by the American Association for Clinical Chemistry.