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Clinical Chemistry 17: 433-437, 1971;
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Clinical Chemistry, Vol 17, 433-437, Copyright © 1971 by the American Association for Clinical Chemistry

Effects of Phenyl Benzo-ggr-Pyrone Derivatives (Flavonoids) on Blood Cell Aggregation: Basis for a Concept of Mode of Action

R. C. Robbins 1

1 Department of Food Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Fla. 32601.

Flavonoids were investigated for activity on blood cell aggregation. A procedure for measuring serial erythrocyte sedimentation rate (ESR) was used to test the effect of five flavonoids (hesperidin, quercetin, rutin, tangeretin, and naringin) on aggregation in vitro. The activity of the flavonoids was compared with that of quinine and low molecular weight dextran (LMD), both of which demonstrably decrease blood cell aggregation in vivo and in vitro. At a blood concentration of 50 µmol/liter the flavonoids, quinine, and LMD all showed significant effects (P < 0.05) on aggregation, the order of retardation of ESR being rutin < quercetin < LMD < hesperidin < quinine < tangeretin. Naringin-treated blood had a higher ESR than control blood. The effect of flavonoids on blood cell aggregation suggests how they may act against increased capillary permeability and fragility, reduce symptoms in disease, and protect against effects of various traumas and stresess.


Key Words: erythrocyte sedimentation rate • quinine • low molecular weight dextran • therapeutic mechanisms

Submitted on February 17, 1971
Accepted on March 16, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.