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Clinical Chemistry 17: 461-474, 1971;
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Clinical Chemistry, Vol 17, 461-474, Copyright © 1971 by the American Association for Clinical Chemistry

Trace-Element Analysis in Clinical Chemistry

Henry A. Schroeder 1 and Alexis P. Nason 1

1 Department of Physiology, Dartmouth Medical School, Hanover, N. H., and the Brattleboro Memorial Hospital, Brattleboro, Vt. 05301.

Present knowledge of human bodily contents and concentrations in blood, urine, and hair of 11 essential trace elements and 17-22 nonessential inert or toxic trace elements is reviewed and summarized. Analyses of trace elements are applicable as diagnostic aids and indices for therapy in a number of clinical conditions. Techniques are not difficult, and analyses will probably become more or less routine for many diseases in which primary or secondary abnormalities are manifest. Trace elements play fundamental roles in human metabolism.


Key Words: micronutrients • diagnostic aids • physiological and abnormal trace elements • carcinogens • vascular disease • normal values






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Copyright © 1971 by the American Association for Clinical Chemistry.