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Clinical Chemistry 17: 495-500, 1971;
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Clinical Chemistry, Vol 17, 495-500, Copyright © 1971 by the American Association for Clinical Chemistry

Quantitative Immunoelectrophoresis of Proteins in Serum from a Normal Population: Season-, Age-, and Sex-related Variations

Jørgen Lyngbye 1 and Jens Krøll 1

1 Department of Clinical Chemistry A, Rigshospitalet, Copenhagen phgr, Denmark.

By use of a quantitative immunoelectrophoretic method, we have determined the concentrations of 15 serum proteins in 260 normal subjects, 8 to 95 years old. An increase with age was found for haptoglobin and IgA, the opposite being the case for albumin and transferrin. For prealbumin, orosomucoid, agr1-lipoprotein, agr1-antitrypsin, ceruloplasmin, agr2-HS-globulin, beta1C-beta1A-globulin, plasminogen, IgG, and IgM only lesser changes with age were seen in adults. The agr2-macroglobulin concentration decreased markedly until the age of 50, after which there was some increase. Sex-associated differences were seen for albumin, orosomucoid, agr1-lipoprotein, agr1-antitrypsin, agr2-macroglobulin, transferrin, beta1C-beta1A-globulin, and the immunoglobulins although not in all age groups. There were opposite and highly significant seasonal variations in ceruloplasmin and agr2-HS-globulin concentrations.

Submitted on February 1, 1971
Accepted on March 15, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.