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Clinical Chemistry 17: 585-586, 1971;
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Clinical Chemistry, Vol 17, 585-586, Copyright © 1971 by the American Association for Clinical Chemistry

Determination of Testosterone Binding Affinity, 17beta-ol Androgens, and Free Androgen Index in Hirsute Women

Carol Pohlman 1, Jeffrey C. Chen 1, Elinor M. Zorn 1, and Ralph G. Wieland 1

1 Department of Endocrinology and Metabolism, Division of Medicine, Saint Luke’s Hospital, Cleveland, Ohio 44104.

Possibly the concentration of free 17beta-ol androgens in blood may be more critical than the total circulating concentration in helping to explain female hirsutism. Total serum 17beta-ol androgens were measured by radioimmunoassay in eight hirsute females. Testosterone binding affinity was assayed in dilute serum with use of Florisil. From this we calculated a free 17beta-ol androgen index (FAI). When compared with concentrations obtained in normal menstruating females, both values were significantly elevated. Adrenocortical suppression resulted in a significant decrease in both 17beta-ol androgens and FAI in the hirsute patients. Thus, we find the determination of 17beta-ol androgens to be as valuable as the FAI in evaluating female hirsutism.


Key Words: free androgen index • polycystic ovary syndrome • adrenal hyperplasia • anovulatory hirsutism • radioimmunoassay • adrenal suppression

Submitted on February 26, 1971
Accepted on April 26, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.