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Clinical Chemistry 17: 592-594, 1971;
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Clinical Chemistry, Vol 17, 592-594, Copyright © 1971 by the American Association for Clinical Chemistry

Profile of Volatile Metabolites in Human Urine

Albert Zlatkis 1 and Hartmut M. Liebich 1

1 Department of Chemistry, University of Houston, Houston, Texas 77004.

Volatile constituents of 30 urines from 10 adults have been studied by gas chromatography, and two also by mass spectrometry. The sample was prepared by extracting urine with ethyl ether, distilling the extract at low temperature under reduced pressure, and concentrating the distillate to a few microliters. High-efficiency capillary columns, 150 m x 0.5 mm i.d., provide the resolution necessary to indicate the presence of some 300 compounds, 40 of which have been identified by mass spectrometry. These include ketones, alcohols, lactones, terpenes, furans, dimethyl sulfone, pyrrole, and allyl isothiocyanate. Dietary changes have a relatively small effect on the profile of the volatiles, and interindividual patterns are very similar. These facts make analyses of this kind of potential diagnostic use.


Key Words: gas chromatography • mass spectrometry • effect of diet • individual variation

Submitted on March 25, 1971
Accepted on April 22, 1971




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R. White
Occurrence of S-methyl thioesters in urines of humans after they have eaten asparagus
Science, September 5, 1975; 189(4205): 810 - 811.
[Abstract] [PDF]


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Copyright © 1971 by the American Association for Clinical Chemistry.