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Clinical Chemistry 17: 602-606, 1971;
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Clinical Chemistry, Vol 17, 602-606, Copyright © 1971 by the American Association for Clinical Chemistry

Determination of Tissue Calcium by Nondestructive Neutron Activation Analysis

Hugh D. Livingston 1

1 Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, N. C. 27103.

A method is described for measuring the concentration of calcium in arterial tissue by neutron activation analysis. The principal advantage is that the method is nondestructive and is ideal for analytical situations in which multiple biochemical measurements are required on a few-milligram sample. Application of the method is illustrated here by a study of aortic calcium metabolism in pigeons and monkeys being used as animal models in experimental atherosclerosis studies. The determination is made on irradiated dry fat-free tissue by using 49Ca (Tfrac12, 8.8 min) to measure calcium. The interference of 37S with the measurement is insignificant. Neutron activation data from one set of tissues were compared with data obtained by atomic absorption spectrophotometry in the same tissues. Good relative agreement was found, although results by atomic absorption were slightly systematically higher than those by neutron activation. Reasons for this are discussed.


Key Words: gamma spectrometry • trace-element measurement • analysis of 0.5-mg tissue samples • calcium in arteriosclerotic aortas of monkeys and pigeons

Submitted on March 23, 1971
Accepted on April 23, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.