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Clinical Chemistry 17: 607-609, 1971;
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Clinical Chemistry, Vol 17, 607-609, Copyright © 1971 by the American Association for Clinical Chemistry

Simultaneous Determination of Trimethadione and Its Metabolite, Dimethadione, by Gas—Liquid Chromatography

H. E. Booker 1 and B. Darcey 1

1 Epilepsy Center, University of Wisconsin Medical Center, Madison, Wis. 53704.

A simple gas chromatographic procedure is described for the measurement of trimethadione and its major metabolite, dimethadione, in serum. The method, with which compounds can be determined on a single extraction and injection, is reliable and free from interference caused by other drugs, particularly those that the patient is likely to be taking in combination with trimethadione.


Key Words: salting out • serum • paramethadione as internal standard • epilepsy therapy

Submitted on April 1, 1971
Accepted on May 4, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.