Clinical Chemistry
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Clinical Chemistry 17: 872-874, 1971;
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Clinical Chemistry, Vol 17, 872-874, Copyright © 1971 by the American Association for Clinical Chemistry

Development of a Screening Test for L-Dopa and Its Metabolites in Urine

J. I. Routh 1 and R. E. Bannow 1

1 Department of Biochemistry, University of Iowa, Iowa City, Iowa 52240.

A simple screening test, sensitive to o-dihydroxyphenyl groups in the urine, was developed for use in monitoring patients with Parkinson's disease who are treated with L-dopa. Compounds measured by this test include dopa, dopamine, 3,4-dihydroxyphenylacetic acid, epinephrine, and norepinephrine. Parallel quantitative experiments, in which ion-exchange chromatography was used, followed by fluorometry and colorimetry, establish the validity of the strip-test results. The test is designed to be used by physician or patient, as well as by clinical laboratory personnel.


Key Words: Parkinson’s disease • ion-exchange chromatography • fluorometry • colorimetry

Submitted on February 16, 1971
Accepted on May 18, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.