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Clinical Chemistry 17: 882-885, 1971;
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Clinical Chemistry, Vol 17, 882-885, Copyright © 1971 by the American Association for Clinical Chemistry

Extra Lactate Dehydrogenase Isoenzyme Band in Serum of Patients with Severe Liver Disease

T. Lubrano 1, A. A. Dietz 1, and H. M. Rubinstein 1

1 Research and Medical Services, Veterans Administration Hospital, Hines, Ill. 60141, and Departments of Biochemistry and Biophysics and Medicine, Loyola University Stritch School of Medicine, Maywood, Ill. 60153.

In a study of lactate dehydrogenase isoenzyme patterns in the sera of patients with severe liver disease, who were primarily selected because of an abnormally high serum bilirubin, 42 of 76 patients had an additional band (LDH-T) between isoenzymes 4 and 5 on acrylamide gel. Thirty of the 42 patients died during followup, 24 within a month of recognition of the extra band.


Key Words: acrylamide-gel electrophoresis • band T

Submitted on April 13, 1971
Accepted on May 17, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.