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Clinical Chemistry 17: 896-902, 1971;
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Clinical Chemistry, Vol 17, 896-902, Copyright © 1971 by the American Association for Clinical Chemistry

Automated Analysis for Drugs in Urine

D. J. Blackmore 1, A. S. Curry 1, T. S. Hayes 1, and E. R. Rutter 1

1 Home Office Central Research Establishment, Aldermaston, Nr. Reading, Berks, England.

Automated methods are described for extracting drugs from urine and for subsequently detecting them by ultraviolet or visible absorptiometry, or by spectrofluorometry. Standard Technicon AutoAnalyzer equipment has been adapted for use in the extraction processes; and manifolds for barbiturates, morphine, and bases are described. For drugs extracted from urine, the limits of detection were 2.5 , µg/ml for barbiturates and 0.2 µg/ml for morphine, Results are given for processing 204-ml samples of urine per hour for morphine and 10 8-ml samples per hour for barbiturate and basic drug analysis.


Key Words: barbiturates, morphine, basic drugs • AutoAnalyzer • automated extractions • drug metabolites • general application to drug determination • spectrophotometry and -fluorometry

Submitted on April 15, 1971
Accepted on May 28, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.