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Clinical Chemistry 17: 915-920, 1971;
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Clinical Chemistry, Vol 17, 915-920, Copyright © 1971 by the American Association for Clinical Chemistry

Changes in the Saccharoid Fraction in Rats with Alloxan-Induced Diabetes or Injected with Epinephrine

M. Jafar Alam 1 and M. Ataur Rahman 1

1 Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

"Saccharoid fraction," defined as the nonglucose reducing substances in blood, increases both in hyperglycemia (blood glucose concentration exceeding 280 mg/dl) and hypoglycemia (blood sugar less than 65 mg/dl) in rats. This increase is not completely accounted for by glutathione, glucuronic acid, ascorbic acid, uric acid, and creatinine. Some of the constituents of saccharoid fraction seem to be insulin-sensitive. Alloxan not only produces diabetes in rats but also increases blood glucuronic acid, ascorbic acid, and uric acid. Estimated constituents of saccharoid fraction account for only 45% to 75% of the saccharoid fraction. The unaccounted-for saccharoid fraction shows changes similar to those in the accounted-for saccharoid fraction, in the diabetic rats, as was also the case after treatment with insulin of normal or diabetic animals. The fraction not accounted for by the estimated constituents may represent the reducing sugar phosphates present in the blood.


Key Words: "true" glucose • sugar phosphates • reducing substances in blood • effect of insulin • glucuronic acid, uric acid, glutathione, ascorbic acid, creatinine

Submitted on April 28, 1971
Accepted on June 7, 1971






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Copyright © 1971 by the American Association for Clinical Chemistry.