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Clinical Chemistry 18: 43-47, 1972;
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Clinical Chemistry, Vol 18, 43-47, Copyright © 1972 by the American Association for Clinical Chemistry

Sephadex Adsorption of Bilirubin from Neonatal and Adult Serum

J. Kapitulnik 1, S. H. Blondheim 1, and N. A. Kaufmann 1

1 Metabolic Laboratory and Departments of Medicine B and Nutrition, Hadassah-University Hospital and Hebrew University—Hadassah Medical School, Jerusalem, Israel.

The bilirubin (BR)-binding capacity of albumin in serum from cord blood, as estimated by Sephadex gel filtration, is less than that of adult serum. The binding site at which BR is tightly bound by albumin in pools of infant serum was saturated at an average BR/albumin molar ratio of 0.66, while in adult serum the ratio was 1.00. With further increase in BR concentration, albumin of infant serum bound BR less than that of adult serum. These findings appear to have clinical significance with respect to the danger of BR encephalopathy in icteric infants.


Key Words: bilirubin-binding capacity of albumin • kernicterus • bilirubin encephalopathy • exchange transfusion

Submitted on August 16, 1971




The following articles in journals at HighWire Press have cited this article:


Home page
 Mol. Pharmacol.Home page
J. Kapitulnik
Bilirubin: An Endogenous Product of Heme Degradation with Both Cytotoxic and Cytoprotective Properties
Mol. Pharmacol., October 1, 2004; 66(4): 773 - 779.
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Copyright © 1972 by the American Association for Clinical Chemistry.