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Clinical Chemistry 18: 1360-1363, 1972;
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Clinical Chemistry, Vol 18, 1360-1363, Copyright © 1972 by the American Association for Clinical Chemistry

Comparison of Rapid Clottable Fibrinogen Assays

Frederick R. Davey 1, Constance E. Carrington 1, and Douglas A. Nelson 1

1 Division of Clinical Pathology, State University of New York, Upstate Medical Center, Syracuse, N. Y. 13210.

Measurements of fibrinogen concentration by use of two rapid methods (clot-weight method and thrombin-turbidity method) were compared with the reference thrombin-coagulation method of Ratnoff and Menzie [J. Lab. Clin. Med. 37, 316 (1951)]. Both rapid methods gave results (in the high, middle, and low ranges) that correlated well with those of the thrombin-coagulation method. However, the thrombin-turbidity method was more precise, easier, and quicker than the clot-weight method.


Key Words: evaluation of disorders of bleeding • normal values • clot-weight method • thrombin-turbidity method • thrombin-coagulation method

Submitted on July 6, 1972
Accepted on July 29, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.