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Clinical Chemistry 18: 1364-1367, 1972;
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Clinical Chemistry, Vol 18, 1364-1367, Copyright © 1972 by the American Association for Clinical Chemistry

Automated Quantitative Immunochemical Analysis of Human Immunoglobulins

Harold Markowitz 1 and A. R. Tschida 1

1 Department of Laboratory Medicine, Mayo Clinic, Rochester, Minn. 55901.

A commercial automated continuous-flow procedure for estimating specific serum proteins has been evaluated for use in determination of IgG, IgA, IgM (both 19S and 7S), agr1-antitrypsin, and cerebrospinal fluid proteins. Results of the automated procedure correlate well with manual methods, but are much more precise. Estimation of 7S IgM by the automated method is more accurate than estimation by radial immunodiffusion, because concentrations of 7S IgM are not spuriously elevated.


Key Words: rases AutoAnalyzer • immunoglobulin quantitation • 7S IgM • nephelometry • correlation of manual and automated results • agr1-antitrypsin • cerebrospinal fluid • multiple sclerosis • radial immunodiffusion • normal values

Submitted on July 10, 1972
Accepted on July 29, 1972




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[Abstract] [PDF]


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Copyright © 1972 by the American Association for Clinical Chemistry.