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Clinical Chemistry 18: 1368-1372, 1972;
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Clinical Chemistry, Vol 18, 1368-1372, Copyright © 1972 by the American Association for Clinical Chemistry

Haptoglobin Phenotype Frequencies in Mentally Retarded Persons

A. T. Rundle 1, B. Clothier 1, and Barbara Sudell 1

1 St. Lawrence's Hospital, Caterham, Surrey, England.

Haptoglobin phenotype frequencies for 887 unselected mentally retarded patients were within the range reported for normal European populations. Of these sera, 2% initially classified as anhaptoglobinemic by subjective appraisal of starch-gel electropherograms were subsequently shown to be hypohaptoglobinemic. This frequency of hypohaptoglobinemia is similar to that reported for normal populations. Sixteen of the hypohaptoglobinemic cases were reinvestigated, and all but one showed some evidence of hepatic dysfunction.


Key Words: starch-gel electrophoresis • serum enzymes, group-specific proteins, haptoglobins • mongolism • tuberous sclerosis • phenylketonuria • hemoglobin • liver-function tests • cellulose acetate electrophoresis • radial immunodiffusion • hepatic disorders and hypohaptoglobinemia

Submitted on April 26, 1972
Accepted on July 31, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.