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Clinical Chemistry 18: 1463-1467, 1972;
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Clinical Chemistry, Vol 18, 1463-1467, Copyright © 1972 by the American Association for Clinical Chemistry

Simplified Primary Screening Procedure for Detection of Hyperlipidemias in Healthy Individuals

Gerald S. Berenson 1, S. R. Srinivasan 1, P. S. Pargaonkar 1, B. Radhakrishnamurthy 1, and Edward R. Dalferes Jr. 1

1 Departments of Medicine and Biochemistry, Louisiana State University School of Medicine, New Orleans, La. 70112.

A simplified primary screening procedure is described for determining serum beta- plus pre-beta-lipoproteins, which is more rapid and less expensive than cholesterol or triglyceride determinations. This method is based on the ability of beta- and pre-beta-lipoproteins to form insoluble complexes with heparin in presence of Ca2+. Comparison with analytical ultracentrifugation indicated the accuracy of concentrations determined by the present method. This method was used to screen a group of healthy adults and children and diabetic patients. The results show that measuring serum beta- plus pre-beta-lipoprotein concentrations may be more useful for screening and detecting subtle abnormalities than is determination of either cholesterol or triglyceride.


Key Words: serum beta- plus pre-beta-lipoprotein index • analytical ultracentrifugation • diabetes • screening • heparin complex • LDL • VLDL

Submitted on July 17, 1972
Accepted on August 31, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.