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Clinical Chemistry 18: 1532-1534, 1972;
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Clinical Chemistry, Vol 18, 1532-1534, Copyright © 1972 by the American Association for Clinical Chemistry

Inhibition of Leukocyte Acid Phosphatase by Heparin

Lawrence R. DeChatelet 1, Charles E. McCall 1, M. Robert Cooper 1, and Pamela S. Shirley 1

1 Departments of Biochemistry and Medicine, The Bowman Gray School of Medicine, Winston-Salem, N.C. 27103.

Low concentrations of heparin (<1 unit/ml) inhibit by 80% the activity of leukocyte acid phosphatase. Leukocyte beta-glucuronidase is less sensitive to heparin, and alkaline phosphatase and lysozyme are unaffected. The possible inhibitory effects of heparin should be considered in all measurements of leukocyte enzymatic activities.

Submitted on August 8, 1972
Accepted on August 31, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.