Clinical Chemistry
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Clinical Chemistry 18: 1537-1538, 1972;
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Clinical Chemistry, Vol 18, 1537-1538, Copyright © 1972 by the American Association for Clinical Chemistry

Effects of Various Medications on Values from the HABA and BCG Methods for Determining Albumin

Solomon Notrica 1, Don S. Miyada 1, Vern Baysinger 1, and Robert M. Nakamura 1

1 Laboratory Procedures Division, Upjohn Co., 6330 Variel Ave., Woodland Hills, Calif. 91364.

We investigated the effects of acetylsalicylic acid, salicylic acid, sulfisoxazole, and phenobarbital—at concentrations at or just above those in serum after therapy—on results of the 2-(4'-hydroxyazobenzene) benzoic acid (HABA) and bromcresol green (BCG) methods for measuring serum albumin. Although the HABA method was more prone to such interference, only interference by salicylic acid with the HABA method is significant. Salicylic acid at a concentration of 400 mg/liter decreases the apparent values for HABA-albumin by about 10%.

Submitted on April 10, 1972






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Copyright © 1972 by the American Association for Clinical Chemistry.