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Clinical Chemistry 18: 116-123, 1972;
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Clinical Chemistry, Vol 18, 116-123, Copyright © 1972 by the American Association for Clinical Chemistry

Diagnostic Effectiveness of Electrophoresis and Specific Protein Assays, Evaluated by Discriminate Analysis

Mario Werner 1, Samuel H. Brooks 1, and Georg Cohnen 1

1 Division of Laboratory Medicine, Washington University, Barnes Hospital, St. Louis, Mo. 63110 (M. W.); School of Medicine, University of Southern California, Los Angeles, Calif. (S. H. B.); and the Department of Medicine, Klinikum Essen, Ruhr Universität Bochum, West Germany (G. C.).

With use of the serum protein pattern as a model, we compared the "Diagnostic Effectiveness" of tests of different chemical specificity—i.e., the percentage classified correctly according to the clinical diagnosis. When results obtained from a selected population of subjects with selected diseases were evaluated by multivariate analysis, disease discrimination by paper electrophoresis, which resolves only chemically heterogeneous fractions, was similar to that of a battery of specific assays for individual proteins.


Key Words: multivariate discriminant analysis • paper electrophoresis vs. specific immunomethods for proteins in diagnosis






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Copyright © 1972 by the American Association for Clinical Chemistry.