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Clinical Chemistry 18: 131-136, 1972;
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Clinical Chemistry, Vol 18, 131-136, Copyright © 1972 by the American Association for Clinical Chemistry

Determination of Serum Acid Phosphatase Activity: A Performance Evaluation for Clinical Laboratories of Upstate New York

William H. Copeland 1 and Raymond E. Vanderlinde 1

1 Division of Laboratories and Research, New York State Department of Health, Albany, N. Y. 12201.

Determination of acid phosphatase activity in clinical laboratories in New York State was evaluated. After the target values were established by 12 reference laboratories, sets of test samples were mailed over a two-year period on three occasions to, respectively, 264, 242, and 239 laboratories. Their initial (1968) results revealed problems: definition of normal ranges, interchange of specimens, standardization and quality control, and a need for improved techniques. Almost 5% of laboratories interchanged the initial specimens. Unexpectedly, laboratories using the same method reported a two-fold or greater variation in their "normal range." Although there was some improvement after refresher training sessions, performance was more clearly improved a year later for five of the seven major methods used. Use of the Bessey—Lowry—Brock, Babson—Phillips, and Shinowara—Jones—Reinhart methods resulted in the lowest coefficients of variation.


Key Words: training programs, effects on results • results, expression of • stability of enzyme • interlaboratory evaluation • intercomparison, results of seven methods

Submitted on June 25, 1971
Accepted on October 22, 1971






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Copyright © 1972 by the American Association for Clinical Chemistry.