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Clinical Chemistry 18: 155-160, 1972;
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Clinical Chemistry, Vol 18, 155-160, Copyright © 1972 by the American Association for Clinical Chemistry

Determination of Ionized Calcium in Serum by Use of an Ion-Selective Electrode

I. Determination of Normal Values under Physiologic Conditions, with Comments on the Effects of Food Ingestion and Hyperventilation

Bette Seamonds 1, Javad Towfighi 1, and Dan A. Arvan 1

1 William Pepper Laboratory, Department of Pathology, University of Pennsylvania, Philadelphia, Pa. 19104.

Ionized calcium was determined in serum from 84 normal individuals by using a flow-through calcium-selective electrode operated at 37°C. The mean value was 1.08 ± 0.06 (2 SD) mmol/liter. The relationship of serum ionized calcium concentration to other serum constituents was examined. The effects of hyperventilation and food ingestion on ionized calcium were studied. Respiratory alkalosis, induced by hyperventilation, caused a decrease in ionized calcium of 0.05 ± 0.02 (2 SD) mmol/liter per 0.1 unit increase in pH. In contrast, the metabolic alkalosis induced by food ingestion caused a decrease in ionized calcium of 0105 ± 0.025 (2 SD) mmol/liter per 0.1 unit increase in pH.


Key Words: respiratory and metabolic alkalosis • total calcium • AutoAnalyzer #{ 149} exogenous and endogenous factors affecting serum calcium • correlations between states of serum calcium • pH, phosphate

Submitted on June 25, 1971
Accepted on October 27, 1971






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Copyright © 1972 by the American Association for Clinical Chemistry.