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Clinical Chemistry 18: 161-163, 1972;
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Clinical Chemistry, Vol 18, 161-163, Copyright © 1972 by the American Association for Clinical Chemistry

Tyrosinemia Induced by a Pyridoxine Antagonist, Desoxypyridoxine

E. Joanne Easton 1, Ian Simpson 1, J. Kenneth Martin 1, and Donald J. Campbell 1

1 Departments of Paediatrics and of Clinical Pathology, University of Alberta Hospital, Edmonton 61, Alberta, Canada.

Tyrosinemia was produced in Wistar rats by feeding a diet deficient in vitamin B6, and containing 1 mg of 4-desoxypyridoxine (DOP) per 100 g of diet. Concentrations of serum tyrosine were greatest in lactating rats, with smaller increases in nonpregnant, nonlactating females and adult males. Paper chromatography of urine indicated that DOP feeding also probably inhibits formation of most normal urinary metabolites of tyrosine. Livers of several rats showed no evidence of cirrhosis after 18 days on the diet containing DOP, indicating that this experimentally produced tyrosinemia is not a true model of tyrosinosis.


Key Words: rats • tyrosinosis • diagnoss of B6 deficiency

Submitted on July 2, 1971






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