Clinical Chemistry
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Clinical Chemistry 18: 209-211, 1972;
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Clinical Chemistry, Vol 18, 209-211, Copyright © 1972 by the American Association for Clinical Chemistry

Interference in Pisano’s Urinary Metanephrine Assay after Use of X-Ray Contrast Media

LaVell R. Johnson 1, Max Reese 1, and Don H. Nelson 1

1 Departments of Medicine, Latter-Day Saints Hospital, and University of Utah, Salt Lake City, Utah 84103.

Certain radiopaque dyes ("Renovist" and "Renografin") contain methylglucamine salts of diatrizoate, which interfere in the Pisano cationexchange method for measuring urinary metanephrine. Methylglucamine is adsorbed to the resin and eluted with the metanephrines. It then consumes the periodate, preventing oxidation of the metanephrines to vanillin and leading to falsely negative results. The methylglucamine can be separated from the metanephrines by adsorbing the metanephrines on QAE Sephadex A-25 acetate at pH 11.2.


Key Words: falsely negative results for pheochromocytoma • methylglucamine as interferant • QAE Sephadex chromatography

Submitted on October 26, 1971
Accepted on November 8, 1971




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Copyright © 1972 by the American Association for Clinical Chemistry.